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GPCR Drug Discovery

Mission statement

The GPCR drug discovery group is focussed on the functionality of G protein coupled receptors (GPCRs) in the context of CNS-related disorders taking into account: receptor plasticity, activation mechanism, signaling bias, ligand binding, the effect of the membrane and other interaction partners. The final goal is to translate obtained molecular insights into the design of drug candidates with improved therapeutic profiles. Jana Selent is the group leader.



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