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Seminars, events & talks

Wednesday, 4th November, 2015, 12.00-13.00

Integrative Biomedical Informatics

New generation biomarkers based on mechanistic insight into disease

The impact of the genomic revolution in the field of medicine has been enormous. The concept of personalized medicine has evolved to precision medicine, which aims to find better ways of defining diseases by relating conventional clinical-pathological diagnostic criteria with state-of-the-art molecular profiling methodologies. Besides, a more precise diagnostic of the disease, based on the description of their molecular mechanisms would allow creating innovative diagnostic, prognostic, and therapeutic strategies precisely tailored to each patient's requirements. To achieve this, a deeper, systems-based understanding of these disease drivers is required. Here I will discuss how primary gene expression and gene variation data can be integrated and transformed into mechanism-based biomarkers containing higher-level information on disease mechanisms by means of relatively simple models of functional pathways. 

Speaker: Joaquín Dopazo, Head of Computational Genomics Dept., CIPF, Valencia, Spain

Room Ramón y Cajal Room

Friday, 12th December, 2014

Integrative Biomedical Informatics

II Bioinformatics and Computational Biology Symposium

This event, jointly organized by the Societat Catalana de Biologia (SCB) and Bioinformatics Barcelona (BIB) will take place at the Institut d'Estudis Catalans on the 12th of December 2014 and  will have four great Keynote speakers and a selection of 8 abstracts for the oral presentations. Additional information can be found in this Web site: Registration closes: 30th of November 2014

Speaker: John Overington (EBI-EMBL), David Posada (U. Vigo), Alfonso Valencia (CNIO), Ramon Maspons (AQuAS)

Room Institut d'Estudis Catalans

Wednesday, 10th December, 2014, 18:45

Integrative Biomedical Informatics

Real world data from Catalonia

This talk is included in the agenda of the European Medical Information Framework (EMIF) Colloquium.

The event will be held on December 10, between 18:00 - 20:00 at the Barcelona Biomedical Research Park (PRBB) auditorium. It will be followed by a networking drink on the PRBB terrace.  There will be simultaneous interpretation available. Please register your attendance by 30th November at For more information on the EMIF Project see website:

Speaker: Ferran Sanz, Director of GRIB

Room PRBB Auditorium

Tuesday, 11th November, 2014

Integrative Biomedical Informatics

b·debate "Big Data in Biomedicine. Challenges and opportunities". Sanz, Ferran. Comitè organitzador

Barcelona, 11-12/11/2014. organitzada juntament amb Bioinformatics Barcelona (BIB),  European Bioinformatics Institute (EMBL-EBI), Biocat i Fundació La Caixa.

Monday, 10th November, 2014, 12:30

Integrative Biomedical Informatics

Bioinformatics in the Era of Big Data

Bio{medical}informatics is a field that has emerged through the analysis of data primarily generated by other researchers. As such it is a leading indicator for what biomedical research will involve in the era of big data, taken here to imply large diverse datasets at different biological   scales - from molecules to populations. Does the model by which we have accessed such data thus far scale to the future? I will argue that the answer is no and new approaches are needed which would change how we do our science.

Speaker: Philip E. Bourne, Associate Director for Data Science (ADDS) at the National Institutes of Health (USA)

Room Ramon y Cajal

Friday, 17th October, 2014, 9:30 - 11:30

Integrative Biomedical Informatics

Bioinformatics: how it can support the FIC?

WHO-FIC Network. World Health Organization - Family of International Classification Annual meeting 11-17 October, 2014, Barcelona The WHO-FIC network is an International collaboration that aims to promote the appropriate selection of classifications in the range of settings in the health field across the world. The primary mandate of the Collaborating Centres for the WHO Family of International Classifications (WHO-FIC) is to support and promote the development and use of WHO classifications such as ICD (the International Classification of Diseases) and ICF (the International Classification of Functioning and Disability) in support of health and health services.

Speaker: Ferran Sanz

Room Centre de Convencions Internacional de Barcelona (CCIB) Plaça de Willy Brandt 11-14 - Barcelona

Tuesday, 1st July, 2014, 15.30-16.30

Integrative Biomedical Informatics

Systems Biology approaches to cellular metabolism: new possibilities for biopharma industry

Speaker: Francis Planes, Mechanical Enginering at School of Engineering at the University of Navarra.

Room Ramón y Cajal Room, PRBB.

Wednesday, 22th January, 2014, 12:00

Integrative Biomedical Informatics

Integrative strategies for biomedical knowledge.

The progress in biomedical research is increasingly hampered by the difficulty of managing and jointly exploiting the huge amount of information that is accumulated and that it is often fragmented into silos. Consequently, the biomedical knowledge discovery can deeply benefit from scientific, technological and organisational advances in the ways that biomedical information is integrated and jointly analysed. Examples of efforts that we are doing in this direction are: 1) the IMI eTOX project, which tries to advance in the in silico prediction of the potential in vivo toxicity of drug candidates by means of information sharing among the pharmaceutical companies and the application of multi-level modelling strategies; 2) DisGeNET, which is a gene-disease database created by integration of gene-disease associations from several resources; 3) the EU-ADR project, which has developed innovative pharmacovigilance strategies by means of joint exploitation of millions of European healthcare records followed by bioinformatics substantiation of the drug-event signals detected; and 4) the recently started IMI EMIF project, which aims to develop a common information framework of patient-level data that will link up and facilitate access to diverse medical and research data sources, opening up new avenues for research.

Speaker: Ferran Sanz, professor of Biostatistics and Biomedical Informatics at Pompeu Fabra University (UPF) and Director of the IMIM-UPF Research Programme on Biomedical Informatics (GRIB).

Room PRBB Auditorium

Monday, 9th December, 2013

Integrative Biomedical Informatics

DisGeNET RDF and its implementation in Open PHACTS

SWAT4LS 2013 – International Semantic Web Applications and Tools for Life Sciences Workshop in Edinburgh (UK)

Speaker: Nuria Queralt - Integrative Biomedical Informatics group (GRIB)

Wednesday, 18th September, 2013, 16:30

Integrative Biomedical Informatics

Unfolding diversity: Modeling promiscuity and toxicity in the metabolic space and beyond.

The development of in silico whole-cell model organisms is helping to build the interface between high-throughput biological data and predictive biology. I will present the work of our group based on metabolic circuits to design and optimize biological devices for production, sensing and regulation [1], introducing proof-of-concept applications of such devices for smart therapeutics and synthetic biology. Our approach is formally described through graph balance analysis, providing a methodology that can be used to study diverse coupling mechanisms such as promiscuous interactions [2] or toxicity pathways [3]. The integration of pathway information with whole-cell models might ultimately unveil unexpected synergistic effects originated from system perturbations.

[1] Carbonell P., Planson A.G., Fichera D., Faulon J.L. A retrosynthetic biology approach to metabolic pathway design for therapeutic production. BMC Systems Biology, 5:122, 2011.

[2] Carbonell P., Faulon J.L., Molecular signatures-based prediction of enzyme promiscuity. Bioinformatics, 26(16):2012-2019, 2010.

[3] Planson A.G., Carbonell P., Paillard E., Pollet N., Faulon J.L. Compound toxicity screening and structure-activity relationship modeling in Escherichia coli. Biotechnology and Bioengineering, 109:846-850, 2012.

Speaker: Pablo Carbonell, Institute of Systems and Synthetic Biology (iSSB), Univ. Evry, CNRS, Evry, France.

Room Charles Darwin (PRBB)

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