Continuing with the OPEN GRIB SEMINARS we organise at the GRIB, we will have a guest who will give the next seminar. So, next Wednesday 29 May 2024 at 15.30 h in Xipre’s room, will take place the next Open GRIB Seminar “ Whole-transcriptome spatial molecular imaging of Tubullovillous adenomas”, by Helena Crowell.
Helena Crowell is a postdoctoral researcher at the group of Holger Heyn in the National Center for Genomic Analysis (CNAG) since September 2023. Previously, she had obtained her PhD at the University of Zurich under the supervision of Mark Robinson, working on the development of computational methods for the analysis of single-cell and spatially resolved omics data. She currently works on the analysis of spatial transcriptomics data in cancer and is an active contributor to the Bioconductor project, where she is also a member of its Technical Advisory Board.
Here you have the abstract:
Recent spatial molecular imaging (SMI) technologies can profile tissues at molecular resolution under retention of physical coordinates — albeit limited in the number of (transcript) targets measurable thus far. We have acquired whole-transcriptome SMI data on colon tissue sections that cover the full range of tumor evolution, including normal epithelia as well as progression to colorectal cancer (CRC) via premalignant Tubullovillous adenoma (TVA) lesions that can give rise to different CRC subtypes. In addition, we leveraged single-cell data (from snPATHO-seq) on adjacent slices for semi-supervised annotation of cell subpopulations. In this talk, I will present a multi-dimensional, holistic view of our results — encompassing whole-transcriptome single-cell and SMI data, pathology-guided as well as semi- and unsupervised computational, well-established and problem-tailored analysis approaches.