The Bioinformatics Unit (BU), led by Júlia Perera, is part of the the MARGenomics platform from the scientific and technical services of the Hospital del Mar Research Insitute. We provide computational support to process high-throughput omics data (eg. NGS, microarrays) with a special focus on translational research. Each type of omics data provides a complementary medical perspective of a biological system or an individual. Therefore, it represents a major opportunity to understand the biological basis of complex diseases, sensitivity and resistance mechanisms to treatments, as well as for the development of predictive biomarkers. We have an extensive background in the field of cancer research but have also been involved in projects related to COVID, chronic urticaria, and major depressive disorder, among other diseases. Our current interest is to integrate multiple NGS data for the detection of patterns/signatures preserved in different pathologies.
The facility currently maintains standardized data processing pipelines for NGS analyses (eg. QC, RNASeq, WES, ChIP-Seq, ATAC-Seq, single cell, differential expression), but also performs advanced analysis tailored to each project (eg. predictive algorithms, biomarker discovery, WGCNA, deconvolution, multi-omics integration). Moreover, we can provide training and consultations in bioinformatics, biostatistics and experimental design. You can visit our GitHub page at https://github.com/margenomics.
