GRIB. Research Unit on Biomedical Informatics





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Congratulations to Núria López-Bigas for the XI Banco Sabadell Foundation Award for Biomedical Research

The Jury of the Award for Biomedical Research of the Banco Sabadell Foundation decided to give this prize to Núria López-Bigas, leader of the Biomedical Genomics group of GRIB (UPF-IMIM), for her contribution to the development of new bioinformatics methods to study cancer genomes. Her work opens up new avenues for the classification of cancer patients according to their tumors carry mutations and thus advance the implementation of the most appropriate individualized for each patient therapies.

"This award helps to give visibility to the Biomedical Research and lets the society know the people who do research. It is a social recognition of the work we do and it is an honor for me that the research done in my group has been recognized" said Núria when knowing the news."In Barcelona, high quality biomedicine research is made with leading research groups in this field to develop high-impact projects for society. For me, it is a luxury to do research in this environment and appear next to the remains of scientists who have been honored with this award".

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Albert Antolín and María Martí

Two doctoral students of GRIB awarded with the Doctoral School PhD Extraordinary Prize of the PhD Programme in Biomedicine of the UPF

Seven PhD Extraordinary Awards have been given of a total of 75 PhD theses defended in the academic year 2014-2015. Albert Antolín and Maria Martí have been awarded with this extraordinary Prize of the PhD Programme in Biomedicine.

The thesis of Albert Antolín, directed by Dr. Jordi Mestres, head of the Systems Pharmacology Group of GRIB, was entitled "The Impact of Polypharmacology on Chemical Biology" and focused on the selectivity of small molecules on their target proteins and its implications on pharmacological safety.

The thesis of Maria Martí, directed by Dr. Manuel Pastor and Dr. Jana Selent, head and PI respectively of the PharmacoInformatics group of GRIB, was entitled "Ligand selectivity at GPCRs: from multi-target binding profiles to biased agonism" and focused on the detection of molecules that enable the development of more efficient and secure antipsychotic drugs.

Albert Antolín is currently a Marie Curie Tecniospring postdoctoral fellow at the Hospital del Mar Medical Research Institute (IMIM) and María Martí is currently a postdoctoral fellow at the Institute of Pharmaceutical Chemistry of the Philipps University of Marburg, Germany. We congratulate both for this award!

The PhD Extraordinary Prizes will be officially presented at the UPF Graduation Ceremony for master's and doctoral degrees that will take place on July 1st, 2016, at the Ciutadella Campus. 

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Last project

NONCODRIVERS

The project NONCODRIVERS "Finding noncoding cancer drivers", aims to characterize the role of mutations in non-coding regions in the most prevalent tumours of the population. The work will count with the collaboration of the International Cancer Genome Consortium, an organization created for the classification of the molecular profile of 50 different types of cancer. The project aims to identify those non-coding alterations that are more relevant for tumour biology through computational methods and will explore new therapeutic strategies that can revert its effects by means of the creation of the corresponding cellular models. The project​ is funded for the period 2016-2021 by the European Research Council (ERC) with an ERC Consolidator grants given to Nuria López-Bigas, head of the Biomedical Genomics group of GRIB.

http://bg.upf.edu/blog/2016/02/erc-consolidator-granted-to-our-lab-to-find-noncoding-cancer-drivers/

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Last publications

  • Queralt-Rosinach N, Piñero J, Bravo A, Sanz F, Furlong LI. DisGeNET-RDF: Harnessing the Innovative Power of the Semantic Web to Explore the Genetic Basis of Diseases. Bioinformatics, 2016. DOI: 10.1093/bioinformatics/btw214.
  • Pages A, Dotu I, Guigo R, Eyras E. The discovery potential of RNA processing profiles. bioRxiv, 2016. DOI: 10.1101/049809.
  • Sabarinathan R, Mularoni L, Deu-Pons J, Gonzalez-Perez A, Lopez-Bigas N. Nucleotide excision repair is impaired by binding of transcription factors to DNANature, 2016; 532 (7598): 264-7. PMID: 27075101 . DOI: 10.1038/nature17661.
  • Sebestyen E, Singh B, Miñana B, Pages A, Mateo F, Pujana MA, Valcarcel J, Eyras E. Large-scale analysis of genome and transcriptome alterations in multiple tumors unveils novel cancer-relevant splicing networks. Genome Research, 2016. DOI: 10.1101/ gr. 199935. 115.

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