GRIB. Research Unit on Biomedical Informatics

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​Project EU-ToxRisk and US Initiative Tox21 will collaborate on efforts to reduce the use of animals​ and achieve more efficient toxicity risk assessment

The EU-ToxRisk project and the Toxicology in the 21st Century (Tox21) initiative in the US have agreed to collaborate on efforts to reduce the use of animals and achieve more efficient chemical safety assesments. A total of 28 representatives from both projects gathered in a workshop held in Mainz (Germany) on the 12th-14th September 2016 to initiate collaboration across areas of mutual interest within the field of risk assessment.

Two groups of GRIB participate in the EU-ToxRisk project coordinating the application of computational methods: the PharmacoInformatics group led by Manuel Pastor and the Integrative Bioinformatics group led by Ferran Sanz, and therefore will play a major role in this collaboration. In particular, the GRIB will participate in the joint development and validation of core methodologies for hazard and risk assessment, as read-across, quantitative AOP and similarity metrics.

You can find further information in the EU-ToxRisk-Tox21 joint Press Release (in english) and the translation into catalan and spanish at the UPF website.

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Computational Genomics group is now Computational RNA Biology group

In its 10th anniversary, the GRIB group led by Eduardo Eyras changes its name to "Computational RNA Biology group" to reflect the contributions by the group during these past years and its well-recognized expertise in the study of different aspects of RNA using computational methods, including RNA structure, RNA splicing regulation, chromatin and RNA, alternative splicing, non-coding RNAs, as well as the relevance of RNA biology in cancer. You can read more about the activities of the group in this web and also at the new group website:

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Last project


EU-ToxRisk: "an integrated european 'flagship' program driving mechanism-based toxicity testing and risk assessment for the 21st century" is a H2020 supported collaborative project for the period 2016-2021 in which academia joins forces with small and medium-sized enterprises (SMEs), large industry, contract research organisations (CROs) and regulatory bodies to achieve a paradigm shift in toxicology towards a more efficient and animal-free chemical safety assessment.

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Last publications

  • Rubio-Perez C, Deu-Pons J, Tamborero D, Lopez-Bigas N, Gonzalez-Perez A. Rational design of cancer gene panels with OncoPaD. Genome Med, 2016; 8(1):98. PMID: 27716338 .
  • Antolin AA, Workman P, Mestres J, Al-Lazikani B. Polypharmacology in Precision Oncology: Current Applications and Future Prospects. Curr Pharm Des, 2016. PMID: 27669965 .
  • Carbonell P, Lopez O, Amberg A, Pastor M, Sanz F. Hepatotoxicity prediction by systems biology modeling of disturbed metabolic pathways using gene expression data. ALTEX-Altern Anim Ex, 2016. PMID: 27690270 . DOI: 10.14573/altex.1602071.
  • Gubern A, Joaquin M, Marquès M, Maseres P, Garcia-Garcia J, Amat R, González-Nuñez D, Oliva B, Real FX, de Nadal E, Posas F. The N-terminal phosphorylation of RB by p38 bypasses its inactivation by CDKs and prevents proliferation in cancer cells. Molecular Cell, 2016. PMID: 27642049 . DOI: 10.1016/j.molcel.2016.08.015.

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