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High levels of CPEB4 expression in human melanoma. The image shows a melanoma biopsy stained for CPEB4 factor (in red) and one of its target genes (RAB27, in green). /CNIO

A protein that defines the melanoma blueprint

A recent publication at Nature Communications identified a new factor essential for the development of these aggressive tumours: the CPEB4, a protein that is crucial for melanoma cell survival. This protein helps to define aspects that distinguish melanoma from other types of cancer. 

The Computational RNA Biology group of GRIB led by Eduardo Eyras has participated on this study  headed by Marisol Soengas from the Spanish National Cancer Research Centre (CNIO), senior author of this paper, an expert in researching the "identity" of melanomas.

Reference article: Lineage-specific roles of the cytoplasmic polyadenylation factor CPEB4 in the regulation of oncogenic drivers in melanoma. Eva Pérez-Guijarro, Panagiotis Karras, Metehan Cifdaloz, Raúl Martínez-Herranz, Estela Cañón, Osvaldo Graña, Celia Horcajada, Direna Alonso-Curbelo, Tonantzin G. Calvo, Gonzalo Gomez, Nicolas Bellora, Erica Riveiro-Falkenbach, Pablo Otiz-Romero, José Luis Rodríguez-Peralto, Lorena Maestre, Giovanna Roncador, Juan C de Agustín Asensio, Colin R. Goding, Eduardo Eyras, Diego Megías, Raúl Méndez and María S. Soengas. Nature Communications (2016). DOI:

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Thesis defence of Àlex Bravo Serrano: "BeFree: a text mining system for the extraction of biomedical information from the literature"

Next Monday, 28th of November at 11:00, Àlex Bravo Serrano, member of the Integrative Biomedical Informatics group of GRIB will defense his thesis "BeFree: a text mining system for the extraction of biomedical information from the literature" at Josep Marull room of the Universitat Pompeu Fabra.

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Last project


EU-ToxRisk: "an integrated european 'flagship' program driving mechanism-based toxicity testing and risk assessment for the 21st century" is a H2020 supported collaborative project for the period 2016-2021 in which academia joins forces with small and medium-sized enterprises (SMEs), large industry, contract research organisations (CROs) and regulatory bodies to achieve a paradigm shift in toxicology towards a more efficient and animal-free chemical safety assessment.

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Last publications

  • Martin S, Bellora N, Gonzalez-Vallinas J, Irimia M, Chebli K, de Toledo M,  Raabe M, Eyras E, Urlaub H, Blencowe B, Tazi J. Preferential binding of a stable G3BP ribonucleoprotein complex to intron-retaining transcripts in mouse brain and modulation of their expression in the cerebellum. J Neurochem, 139 (3): 349-368. PMID: 27513819 . DOI: 10.1111/jnc.13768 NOV 2016.
  • Pérez-Guijarro E, Karras P, Cifdaloz M, Martínez-Herranz R, Cañón E, Graña O, Horcajada-Reales C, Alonso-Curbelo D, Calvo TG, Gómez-López G, Bellora N, Riveiro-Falkenbach E, Ortiz-Romero PL, Rodríguez-Peralto JL, Maestre L, Roncador G, de Agustín Asensio JC, Goding CR, Eyras E, Megías D, Méndez R, Soengas MS. Lineage-specific roles of the cytoplasmic polyadenylation factor CPEB4 in the regulation of melanoma drivers. Nat Commun. 2016 Nov 18;7:13418. PMID: 27857118 . DOI: 10.1038/ncomms13418.
  • Al-Shorbaji N, Bellazzi R, de Quiros FGB, Kochs S, Kulikowski CA, Lovell NH, Maojo V, Park HA, Sanz F, Sarkar IN, Tanaka H. Discussion of "The New Role of Biomedical informatics in the Age of Digital Medicine". Methods Inf Med, 55 (5): 403-421. PMID: 27524112 . DOI: 10.3414/ME15-12-0005 2016.
  • García-Martín JA, Bayegan AH, Dotu I, Clote P. RNAdualPF: software to compute the dual partition function with sample applications in molecular evolution theory. BMC Bioinformatics, 2016; 17(1): 424. PMID: 27756204 .

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