GRIB. Research Unit on Biomedical Informatics





News & activities

Graphic abstract of the article - Cell Reports

Alternative splicing, an important mechanism for understanding cancer

Using data for more than 4,000 cancer patients from The Cancer Genome Atlas (TCGA project), a team led by Eduardo Eyras, ICREA research professor at the UPF and head of the Computational RNA Biology group of GRIB (IMIM-UPF) jointly with the Sanford Burnham Prebys Medical Discovery Institute in San Diego has analyzed the changes in alternative splicing that occur in each tumor patient and studied how these changes could impact the function of genes. The results of the study, published in the journal Cell Reports, show that alternative splicing changes lead to a general loss of functional protein domains, and particularly those domains related to functions that are also affected by genetic mutations in cancer patients.

"Thanks to our previous research, we know that tumor type and stage can be predicted by observing alterations in alternative splicing", says E.Eyras, and adds, "with this new study, we have discovered that changes in alternative splicing that occur in cancer impact protein functions in a way that is similar to that previously described for genetic mutations".

Reference work: Climente-González, Héctor, Eduard Porta-Pardo, Adam Godzik, Eduardo Eyras. "The Functional Impact of Alternative Splicing in Cancer". Cell Reports, 2017; 20 (9): 2215-2226.

More info...

40 Million EUR european project for new drug safety assessment and integrative data analysis research

The five-year project eTRANSAFE: Enhancing Translational Safety Assessment through Integrative Knowledge Management, aims to develop an advanced data integration infrastructure together with innovative computational methods to improve the security in drug development process and is funded by the Innovative Medicines Initiative (IMI 2) together with the pharmaceutical industry.

The eTRANSAFE consortium is a private and public partnership of 8 academic institutions, 6 SMEs and 12 pharmaceutical companies, and is coordinated by the Fundació Institut Mar d'Investigacions Mèdiques (IMIM) and led by the pharmaceutical company Novartis. Universitat Pompeu Fabra and Synapse Research Management Partners are partners of the Consortium. 

Based on the experience gained in the previous eTOX project, the eTRANSAFE project will carry out key efforts in the field of data standardisation and quality control, promoting the development and implementation of relevant data sharing policies and procedures that will have a great global impact in the community. eTRANSAFE will catalyse the transformation of drug safety modelling from monolithic applications and isolated data repositories to an open innovation ecosystem based on open standards, modular components and data integration services.

Professor Ferran Sanz, coordinator of the project said: "eTRANSAFE will improve translational safety assessment and contribute to the key scientific policies, such as the reduce, replace, refine (3Rs) one and the FAIR principles for data sharing."

More info...

More news RSS

Last project

eTRANSAFE

The project eTRANSAFE: Enhancing Translational Safety Assessment through Integrative Knowledge Management, aims to develop an advanced data integration infrastructure together with innovative computational methods to improve the security in drug development process and is funded by the Innovative Medicines Initiative (IMI 2) together with the pharmaceutical industry for the period 2017-2022. 

http://www.etransafe.eu/

More projects

Last publications

  • Climente-González H, Porta-Pardo E, Godzik A, Eyras E. The Functional Impact of Alternative Splicing in Cancer. Cell Rep, 2017; 20 (9): 2215-2226. PMID: 28854369 . DOI: 10.1016/j.celrep.2017.08.012.
  • Azuaje J, López P, Iglesias A, de la Fuente RA, Pérez-Rubio JM, García D, Stępniewski TM, García-Mera X, Brea JM, Selent J, Pérez D, Castro M, Loza MI, Sotelo E. Development of Fluorescent Probes that Target Serotonin 5-HT2B Receptors. Sci Rep, 2017; 7 (1): 10765. PMID: 28883627 . DOI: 10.1038/s41598-017-11370-2.
  • Kapoor A, Martínez G, Provasi D, de Fabritiis G, Filizola M. Dynamic and Kinetic Elements of µ-Opioid Receptor Functional Selectivity. Sci Rep, 2017; 7(1): 11255. PMID: 28900175 . DOI: 10.1038/s41598-017-11483-8.
  • Albà MM. Zinc-finger domains in metazoans: evolution gone wild. Genome Biol, 2017; 18 (1): 168. PMID: 28877710 . DOI: 10.1186/s13059-017-1307-y.

More publications



Site Information